Dr Marcin Zagórski

Contact

room D-2-22
marcin.zagorski[at]uj.edu.pl
Tel: +48 12 664 4724


Marcin Zagorski photo

Research

The development of multicellular organism is a remarkably reproducible process. Cells are exposed to chemical cues that pattern tissues to specify regions of different cell types that will later on give rise to distinct body parts. Despite the intrinsic stochasticity of signaling events and gene expression, at cellular level the signals are interpreted to establish cell fate with striking precision of a few cell diameters. How such remarkable precision is achieved is a fundamental question in biology that is still poorly understood.

My research is focused on unraveling biophysical mechanisms that result in the remarkably precise formation of gene expression patterns (cell fates) in developing organisms. I want to address questions: How is information decoded in developmental systems? What regulatory mechanisms affecting the intracellular signaling enhance patterning precision? How does feedback between source and target tissue alter pattern reproducibility?

To address these questions, I combine methods from theoretical physics with data driven analysis. I work closely with experimental labs that apply cutting-edge techniques to visualize mouse spinal cord formation (Kicheva lab, Briscoe lab). In many cases, the model predictions are verified experimentally bringing new insights about the underlying biological system.

Open positions

I am currently looking for two postdocs and two PhD students.

One postdoc and one PhD student position is available in SONATA project Regulatory mechanisms for reproducible neural pattern specification in the developing spinal cord financed by National Science Center Poland (NCN):

One postdoc and one PhD student position is available in Polish Returns project Principles of information decoding in developmental systems financed by Polish National Agency for Academic Exchange (NAWA):

The job descriptions along with the list of documents to be submitted are in the job announcements. The prospective candidates should contact me at marcin.zagorski[at]uj.edu.pl for any further information. Application deadline is May 17, 2019. However, the positions will remain open until filled by qualified candidates.

Selected publications